Nutrition is critically important for optimum development and maintenance of mind and body throughout life in animals and humans. The focus of my research group is on dietary disease prevention using a “system biology” approach that integrates knowledge from nutrition & physiology, molecular & cellular biology, nutritional & molecular epidemiology, and biostatistics. (1) In ruminants, the focus of my research group is on optimal nutrition during periods of stress, in particular the time around calving and markers that predict risk of disease. Flaxseed, selenium, yeast fermentation product, and vitamin E are dietary compounds that we have looked at for improving health and performance of ruminants. (2) In humans, the focus of my research group is personalized disease prevention using dietary flavonols and dry beans. Combining “omics” techniques in parallel human and animal model studies provides the opportunity to improve risk assessment, allowing the development of new prevention and treatment options, and an individually tailored approach to prevention and treatment in humans.