TitleAHR-dependent misregulation of Wnt signaling disrupts tissue regeneration.
Publication TypeJournal Article
Year of Publication2009
AuthorsMathew, LK, Simonich, MT, Tanguay, RL
JournalBiochem Pharmacol
Date Published2009 Feb 15
KeywordsAnimals, Extremities, Humans, Models, Biological, Polychlorinated Dibenzodioxins, Receptors, Aryl Hydrocarbon, Regeneration, Reproduction, Signal Transduction, Wnt Proteins, Zebrafish

The origins of molecular toxicology can be traced to understanding the interactions between halogenated aromatic hydrocarbons and the aryl hydrocarbon receptor (AHR). The physiological consequences of activation of the aryl hydrocarbon receptor are diverse, and we are just beginning to understand the importance of the AHR signal transduction pathway in homeostasis and disease. The many downstream targets that mediate these biological responses remain undefined. Studies have exploited the power of the zebrafish model to elucidate the mechanisms by which AHR activation disrupts biological signaling. Recent genomic analysis performed in a zebrafish tissue regeneration model revealed functional cross talk between AHR and the well-established Wnt/beta-catenin signal transduction pathway. This review focuses on the development of the zebrafish model of AHR biology and the application of in vivo toxicogenomics to unravel molecular mechanisms.

Alternate JournalBiochem. Pharmacol.
PubMed ID18938144
PubMed Central IDPMC2658594
Grant ListR01 ES010820-06 / ES / NIEHS NIH HHS / United States
P30 ES000210-409017 / ES / NIEHS NIH HHS / United States
R01 ES010820 / ES / NIEHS NIH HHS / United States
R01 ES010820-05 / ES / NIEHS NIH HHS / United States
P30 ES000210 / ES / NIEHS NIH HHS / United States